This talk on multiple sequence alignment was given by Prof Geoff Barton as part of 2016 SLS Postgraduate Computational Training Program on Protein Sequence Analysis (
http://www.compbio.dundee.ac.uk/drsas...). A prerequisite for this set of lectures is basic knowledge of protein structure. We recommend reading the first chapters of "Introduction to Protein Structure" by Branden and Tooze.
The aim of this workshop was to give an understanding of how best to use computational methods to “make sense” of the structure and function of proteins. The workshop introduced the principles of sequence analysis and its relationship to protein structure and function. It highlighted common methods and tools for protein sequence analysis and multiple sequence alignment. The workshop included hands-on examples of methods that exploit evolutionary information to predict structural features from sequence and to identify functionally important residues by sub-family analysis.
Geoff Barton ( http://www.compbio.dundee.ac.uk) is based at the College of Life Sciences ( http://www.lifesci.dundee.ac.uk ) at the University of Dundee ( http://www.dundee.ac.uk). The team have developed a variety of software including software JPRED ( http://www.compbio.dundee.ac.uk/www-j...), JABAWS ( http://www.compbio.dundee.ac.uk/jabaws) and Jalview ( http://www.jalview.org).
The video was produced by Dr Suzanne Duce, School of Life Sciences, University of Dundee
Lecture 2 (Part 3) by Prof Geoff Barton on "How good are alignments?" analysis paralysis | |
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